Blair Mirka's research has included low altitude remote sensing from UAVs, Satellite image processing and photogrammetry, and Structure from Motion (SfM) modeling. Specifically, she has worked on detecting trash fires from satellite imagery and mapping deforestation plots in southern China's Fanjingshan National Nature Reserve.

During her master's program, Mirka was accepted as a Marshall Plan Foundation Scholar to conduct research in Austria. There she was able to test UAV-based thermal detection methods for arboreal primates, evaluate Repeat Station Imagery (RSI) applicability to wildlife monitoring, and test TIR imageries ability to create accurate 3D models using SfM photogrammetric techniques.

Mirka has also been an active member of the American Society for Photogrammetry and Remote Sensing (ASPRS) both at San Diego State University (SDSU) and at the University of New Mexico, where she is the current president of the student chapter.